H R X Involvement in De Novo and Secondary Leukemias With Diverse Chromosome l l q 2 3 Abnormalities
نویسندگان
چکیده
Chromosome band 1 1 q23 is a site of recurrent translocations and interstitial deletions in human leukemias. Recent studies have shown that the 1 1 q23 gene HRX is fused to heterologous genes from chromosomes 4 or 19 after t(4;l l)(q21 ;q23) and t(ll;19)(q23; p l3 ) translocations to create fusion genes encoding proteins with structural features of chimeric transcription factors. In this report, we show structural alterations of HRX by conventional Southern blot analyses in 26 of 27 de novo leukemias with cytogenetically diverse 1 1 q23 abnormalities. The sole case that lacked HRXrearrangements was a t( l1 ;I 7)-acute myeloid leukemia with French-American-British M3-like morphology. We also analyzed 10 secondary leukemias that arose after therapy with topoisomerase II inhibitors and found HRX rearrangements in 7 of 7 with 1 1 q23 translocations, and in 2 of 2 with unsuccessful karyotypes. In
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